John Whyte, MD, PhD

John Whyte

Director, Moss Rehabilitation Research Institute;
Director: TBI Rehabilitation Research Laboratory; Professor of Rehabilitation Medicine, Thomas Jefferson University; Adjunct Professor of Physical Medicine and Rehabilitation; Temple University.

Research interests

  • I am interested in the cognitive impairments that result from brain injury, with an emphasis on traumatic brain injury and disruption of attention and executive processes. My research interests in this area range from basic cognitive mechanisms, to functional imaging, behavioral assessment, and treatment.
  • I am also involved in a program of research related to disorders of consciousness (coma, vegetative and minimally conscious states), including methods for assessing the level of consciousness and treatments that can enhance consciousness
  • An overarching interest is the special methodologic challenges posed by rehabilitation research, which often involves interventions at cellular or process levels with the goal of influencing complex real-world functioning.
  • I am also involved in research career development work on the local and national level, attempting to enhance academic development and career success among rehabilitation researchers.

Current projects

Restoration of consciousness with zolpidem, and exploration of the neural substrate of this response
Assessment and treatment of disorders of consciousness
fMRI correlates of attention and executive function and their response to psychoactive medications
Classification of Measurement of Medical Rehabilitation Interventions – development of a taxonomy of rehabilitation treatments based on "active ingredients"
NIDRR-funded Traumatic Brain Injury Model System
The Rehabilitation Medicine Scientist Training Program – a national research career development program for physiatrists

Selected Publications

Attention/Executive Function

Kim J, Whyte J, Patel S, Avants B, Europa E, Wang J, Slattery J, Gee JC, Coslett HB, Detre JA: Resting CBF alterations in chronic traumatic brain injury: An arterial spin labeling perfusion fMRI study. Journal of Neurotrauma, 27:1399-1411, 2010 PMID 20528163

Hart T, Whyte J, Ellis C, Chervoneva I: Construct validity of an Attention Rating Scale for traumatic brain injury. Neuropsychology, 23(6):729-735, 2009 PMID 19899831

Kim J, Whyte J, Wang J, Rao H, Tang KZ, Detre JA. Continuous ASL perfusion fMRI investigation of higher cognition: quantification of tonic CBF changes during sustained attention and working memory tasks. Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Neuroimage. 31(1):376-85, 2006 PMID 16427324

Whyte J, Hart T, Vaccaro M, Grieb-Neff P, Risser A, Polansky M, Coslett HB: The effects of methylphenidate on attention deficits after traumatic brain injury: A multi-dimensional randomized controlled trial. American Journal of Physical Medicine and Rehabilitation, 83(6):401-420, 2004 PMID 15166683

Disorders of Consciousness

Whyte J, Myers R: Incidence of clinically significant responses to Zolpidem among patients with disorders of consciousness: A preliminary placebo controlled trial. American Journal of Physical Medicine and Rehabilitation, 88(5):410-418, 2009 PMID 19620954

Whyte J, Katz D, Long D, DiPasquale MC, Polansky M, Kalmar K, Giacino J, Childs N, Mercer W, Novak P, Maurer P, Eifert B: Predictors of outcome and effect of psychoactive medications in prolonged posttraumatic disorders of consciousness: A multicenter study. Archives of Physical Medicine and Rehabilitation, 86;(3):453-462, 2005 PMID 15759228

Whyte J, DiPasquale M., Vaccaro M: Assessment of command-following in minimally conscious brain injured patients. Archives of Physical Medicine and Rehabilitation 80:1-8, 1999 PMID 18509503

Rehabilitation Research Methods

Whyte J: Directions in brain injury research: From concept to clinical implementation. Neuropsychological Rehabilitation, 19(6):807-823, 2009 PMID 19548176

Whyte J, Gordon W, Gonzalez-Rothi, L: A phased developmental approach to neurorehabilitation research: The science of knowledge building. Archives of Physical Medicine and Rehabilitation, Archives of Physical Medicine and Rehabilitation, 90(11 Suppl 1):S3-10, 2009 PMID 19892072

Whyte J: A grand unified theory of rehabilitation (We Wish!)". The 57th John Stanley Coulter Memorial Lecture. Archives of Physical Medicine and Rehabilitation, 89;2:203-209, 2008 PMID 18226642

Whyte J, Hart T. It’s more than a black box; it’s a Russian doll: Defining rehabilitation treatments. American Journal of Physical Medicine and Rehabilitation 82(8):639-652, 2003 PMID 12872021

Whyte J: Assessing medical rehabilitation practices: Distinctive methodologic challenges. In Fuhrer MJ (ed.), The Promise of Outcomes Research, Baltimore: Brookes, (2):43-59, 1997

Research Career Development

Whyte J, Boninger M, Helkowski W, Braddom-Ritzler, C: The Rehabilitation Medicine Scientist Training Program: Impact and lessons learned. American Journal of Physical Medicine and Rehabilitation, 88(3): 169 – 179, 2009