Junghoon Kim, PhD

Junghoon Kim

Director, Clinical Neuroimaging Laboratory, Moss Rehabilitation Research Institute
Research Assistant Professor, Department of Rehabilitation Medicine, Thomas Jefferson University

CV (PDF: 139kb / 8 pages)

BA, Psychology, Seoul National University, 1991
MA, Psychobiology, Seoul National University, 1995
PhD, Experimental Psychology, University of Pennsylvania, 2001

Research Interests

I am currently interested in various neurorehabilitation issues in traumatic brain injury including the nature of injury-related cognitive deficit, the predictors of functional recovery, and the mechanisms of treatment efficacy. My lab uses state-of-the-art neuropsychological and neuroimaging tools to study these topics.

Current projects

A longitudinal multi-modal neuroimaging investigation of functional recovery after diffuse traumatic brain injury (funded by NINDS, NIH)
Evaluation of spatial normalization protocols for brains with focal lesions (funded by the Pennsylvania Department of Health)
Restoration of consciousness with zolpidem, and exploration of the neural substrate of this response (collaboration with Dr. John Whyte and the TBI Rehabilitation Research Lab)
fMRI correlates of attention and executive function and their response to psychoactive medications (collaboration with Dr. John Whyte and the TBI Rehabilitation Research Lab)

Publications

Peer-reviewed Journal Publications

Tustison, N. J., Avants, B. B., Cook, P. A., Kim, J., Whyte, J., Gee, J. C., & Stone, J. R. (in press). Logical circularity in voxel-based analysis: Normalization strategy may induce statistical bias. Human Brain Mapping. PMID 23151955

Kim, J., Avants, B. B., Whyte, J., & Gee, C. G. (2013). Methodological considerations in longitudinal structural morphometry of traumatic brain injury. Frontiers in Human Neuroscience, 7: 52. PMCID 3581852

Kim, J., Whyte, J., Patel, S., Europa, E., Wang, J., Coslett, H. B., & Detre, J.A. (2012). Methylphenidate modulates sustained attention and cortical activation in survivors of traumatic brain injury: A perfusion fMRI study. Psychopharmacology, 222: 47-57. PMID 22203319

Kim, J., Whyte, J., Patel, S., Europa, E., Slattery, J., Coslett, H. B., & Detre, J.A. (2012). A perfusion fMRI study of the neural correlates of sustained attention and working memory deficits in chronic traumatic brain injury. Neurorehabilitation and Neural Repair, 26: 870-880. PMID 22357634

Kim, J., Whyte, J., Patel, S., Avants, B., Europa, E., Wang, J., Slattery, J., Gee, J. C., Coslett, H. B., & Detre, J. A. (2010). Resting CBF alterations in chronic traumatic brain injury: An arterial spin labeling perfusion fMRI study. Journal of Neurotrauma, 27:1399-1411. [Cover Article] PMID 20528163

Bachman, P., Kim, J., Yee, C. M., Therman, S., Manninen, M., Lönnqvist, J., Kaprio, J., Huttunen, M., Näätänen, R., & Cannon, T. D. (2009). Efficiency of working memory encoding in twins discordant for schizophrenia. Journal of Psychiatry: Neuroimaging, 174: 97-104. PMID 19853415

Avants, B. B., Duda, J. T., Kim, J., Zhang, H., Pluta, J., Gee, J. C., Whyte, J. (2008). Multivariate analysis of structural and diffusion imaging in traumatic brain injury. Academic Radiology, 15: 1360-1375. PMID 18995188

Kim, J., Avants, B., Patel, S., Whyte, J., Coslett, H. B., Pluta, J., Detre, J. A., & Gee, J. C. (2008). Structural consequences of diffuse traumatic brain injury: a large deformation tensor-based morphometry study. Neuroimage, 39: 1014-1026. PMID 17999940

Bachman, P., Kim, J., Yee, C. M., Therman, S., Manninen, M., Lönnqvist, J., Kaprio, J., Huttunen, R., Näätänen, R., & Cannon, T. D. (2008). Abnormally high EEG alpha synchrony during working memory maintenance in twins discordant for schizophrenia. Schizophrenia Research, 103: 293-297. PMID 18534822

Kim, J., Whyte, J., Wang, J., Rao, H., Tang, Z. K., & Detre, J. A. (2006). Continuous ASL perfusion fMRI investigation of higher cognition: Quantification of tonic CBF changes during sustained attention and working memory tasks. Neuroimage, 31: 376-385. PMID 16427324

Ances, B. M., Roc, A. C., Wang, J., Korczykowski, M., Okawa, J., Stern, J., Kim, J., Wolf, R., Lawler, K., Kolson, D., & Detre, J. A. (2006). Caudate blood flow and volume are reduced in HIV+ neurocognitively impaired patients. Neurology, 66: 862-866. PMID 16567703

Cannon, T. D., Glahn, D. C., Kim, J., Van Erp, T. G. M., Karlsgodt, K., Cohen, M. S., Nuechterlein, K., Bava, S. & Shirinyan, D. (2005). Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophrenia. Archives of General Psychiatry, 62: 1071-1080. PMID 16203952

Kim, J., Whyte, J., Hart, T., Vaccaro, M., Polansky, M., & Coslett, H. B. (2005). Executive function as a predictor of inattentive behavior after traumatic brain injury. Journal of the International Neuropsychological Society, 11: 434-445. PMID 16209424

Hart, T., Whyte, J., Kim, J., Vaccaro, M. (2005). Executive function and self-awareness of “real-world” behavior and attention deficits following traumatic brain injury. The Journal of Head Trauma Rehabilitation, 20: 333-347. PMID 16030440

Kim, J., Glahn, D., Nuechterlein, K., & Cannon, T. (2004). Maintenance and manipulation of information in schizophrenia: Further evidence for impairment in the central executive component of working memory. Schizophrenia Research, 68: 173-187. PMID 15099601

Glahn, D. C., Kim, J., Cohen, M. S., Poutanen, V.-P., Therman, S., Bava, S., Van Erp, T. G. M., Manninen, M., Huttanen, M., Lonnqvist, J., Standertskjold-Nordenstam, C. G., & Cannon, T. (2002). Maintenance and manipulation in spatial working memory: Dissociations in the prefrontal cortex. Neuroimage, 17: 201-213. PMID 12482077

Selected Published Abstracts

Kim, J., Whyte, J., Patel, S., Europa, E., Slattery, J., Coslett, H. B., & Detre, J. A. (2011). A perfusion fMRI study of the neural correlates of working memory deficits in traumatic brain injury. Journal of Neurotrauma, 28(5): A-10.

Kim, J., Whyte, J., Europa, E., Patel, S., & Detre, J. A. (2011). Methylphenidate modulates sustained attention and cortical activation in survivors of traumatic brain injury: A perfusion fMRI study. Journal of the International Neuropsychological Society, 17(S1): 252.

Higier, R. G., Nuechterlein, K. H., Asarnow, R., Shirinyan, D., Kim, J., Kuppinger, H., & Cannon, T. D. (2010). Impairment of executive and storage aspects of spatial working memory in patients with schizophrenia and their first-degree relatives. Biological Psychiatry, 67:84S.

Duda, J. T., Avants, B., Kim, J., Zhang, H., Patel, S., Whyte, J., & Gee, J. C. (2008). Multivariate analysis of thalamo-cortical connectivity loss in TBI. In Computer Vision and Pattern Recognition Workshops (pp. 1-8). Anchorage, AK: IEEE Computer Society.

Bachman, P., Kim, J., Yee-Bradbury, C. M., Therman, S., Manninen, M., Lönnqvist, J., Kaprio, J., Näätänen, R. R., & Cannon, T. D. (2006). Two tests of neural efficiency in schizophrenia patients performing a working memory task. Psychophysiology, 43: S21-S22.

Jetton, C. L., Bachman, P., Kim, J., Yee-Bradbury, C. M., Therman, S., Manninen, M., Lönnqvist, J., Kaprio, J., Näätänen, R. R., & Cannon, T. D. (2006). ERP correlates of working memory dysfunction in schizophrenia patients, their non-schizophrenic co-twins, and controls. Biological Psychiatry, 59(8): 73S.

Kim, J., Whyte, J., Wang, J., Kimberg, D., Boronat, C., Tang, K., & Detre, J. A. (2004). Right hemisphere involvement in a sustained visual discrimination task: A replication with ASL perfusion MRI. Neuroimage, 22, Supplement 1: e1992-3.