Laurel Buxbaum, PsyD

Laurel Buxbaum

Institute Scientist, Moss Rehabilitation Research Institute
Director, Cognition and Action Laboratory
Research Associate Professor of Rehabilitation Medicine, Thomas Jefferson University

BA, Biological Basis of Behavior, University of Pennsylvania, 1982
Psy.D., (Clinical Neuropsychology) Hahnemann University, 1988

Research interests

Examining the role of instructions and task context in object processing and priming/interference by distractor objects using eyetracking and behavioral methods

The role of sensory-motor information in semantic object processing and object recognition

Voxel-based lesion analyses of action and object processing

Relationship of cognitive representations of action and task hierarchy to naturalistic action performance (Naturalistic Action Test)

Assessment and treatment of hemispatial neglect using virtual reality and other methods (Right Hemisphere Stroke Center)

Current projects

- Prediction of action events (with Matthieu De Wit)
- The role of abstract kinematics in movement imitation (with Aaron Wong, John Krakauer, and Steve Jax)
- Implicit priming of tool-related actions (with Christine Watson)
- Virtual reality treatment of phantom limb pain (with Katherine Kuchenbecker and Branch Coslett)
- Facilitating representations of tool use with transcranial Direct Current Stimulation (tDCS) (with Steve Jax)
- Functional connectivity of the tool use network (with Steve Gotts, Alex Martin, and Christine Watson)
- The Right Hemisphere Stroke Center at MossRehab - Business Wire (PDF: 141kb / 1 pages)
- Action and non-action sequencing in the left hemisphere (with Ricarda Schubotz)
- Action Network Strengthening Treatment for apraxia (with Myrna Schwartz and Matthieu De Wit)

Recent Publications

Watson, C., Buxbaum, LJ. A Distributed Network Critical for Selecting Among Tool-Directed Actions. Cortex, In Press.

Jax, SA, *Rosa-Leyra, D., Buxbaum, LJ. Conceptual- and production-related predictors of pantomimed tool use deficits in apraxia. Neuropsychologia, Sep;62:194-201. PMID: 25107676

Watson, C, Buxbaum, LJ. Uncovering the architecture of action semantics. Journal of Experimental Psychology: Human Perception and Performance, 2014 Oct;40(5):1832-48. PMID: 25045905

Lee, C-L, Mirman, D, Buxbaum, LJ. Abnormal dynamics of activation of object use information in apraxia: evidence from eyetracking. Neuropsychologia, 2014, 59:13-26. PMID: 24746946

Buxbaum, L.J., *Shapiro, A.D., Coslett, H.B. Critical brain regions for tool-related and imitative actions: A componential analysis. Brain, 2014 Jul;137(Pt 7):1971-85. PMID: 24776969

*Tsagkaridis, K, Jax, SA, *Watson, C, Buxbaum, LJ. The role of action representations in thematic object relations. Frontiers in Human Neuroscience, 2014 Mar 18;8:140. PMID: 24672461

*Kalénine, S, *Shapiro, A, Buxbaum, LJ. Processing of action means and outcome in left hemisphere stroke. Neuropsychologia, Jun;51(7):1224-33, 2013. PMID: 23566892

Kalénine, S, Shapiro, AD, *Flumini, A, Borghi, AM, Buxbaum, LJ. Visual context modulates potentiation of grasp types during semantic object categorization. Psychonomic Bulletin and Review, Jun;21(3):645-51, 2014, PMID: 24186270

Binkofski F, Buxbaum LJ. Two action systems in the human brain. Brain and Language, 127(2):222-9, 2013, PMID: 22889467

Buxbaum LJ, Dawson AM, Linsley D. Reliability and validity of the Virtual Reality Lateralized Attention Test in assessing hemispatial neglect in right-hemisphere stroke. Neuropsychology. 2012 Jul;26(4):430-41. Epub 2012 May 28. PMID: 22642393

Kalénine S, Mirman D, Buxbaum LJ. A combination of thematic and similarity-based semantic processes confers resistance to deficit following left hemisphere stroke. Front Hum Neurosci. 2012;6:106. Epub 2012 May 4. PMID: 22586383 Free PMC Article

Jax SA, Buxbaum LJ. Response interference between functional and structural object-related actions is increased in patients with ideomotor apraxia. Journal of Neuropsychology, 127(2):222-9, 2013, PMID: 22515637

Kalénine S, Mirman D, Middleton EL, Buxbaum LJ. Temporal dynamics of activation of thematic and functional knowledge during conceptual processing of manipulable artifacts. J Exp Psychol Learn Mem Cogn. 2012 Sep;38(5):1274-95. Epub 2012 Mar 26. PMID: 22449134

Lee, C, *Middleton, E, Mirman, D, Kalenine, S, Buxbaum, LJ. Incidental and context-responsive activation of structure- and function-based action features during object identification. Journal of Experimental Psychology: Human Perception and Performance, Feb;39(1):257-70, 2013, PMID: 22390294

Palluel-Germain R, Jax SA, Buxbaum LJ. Visuo-motor gain adaptation and generalization following left hemisphere stroke. Neurosci Lett. 2011 Jul 12;498(3):222-6. Epub 2011 May 13. PMID: 21605626

Sathian, K. Buxbaum, LJ Cohen, L., Krakauer, J.W., Lang, C., Corbetta, M., and Fitzpatrick, S. M. Neurological principles and rehabilitation of action disorders: common clinical deficits. Neurorehabilitation and Neural Repair. 2011 Jun;25(5 Suppl):21S-32S. Review. PMID: 21613535

Kalénine, S, Buxbaum, LJ, Coslett, HB. Critical brain regions for action recognition: lesion-symptom mapping in left hemisphere stroke. Brain, Nov;133(11):3269-80, 2010. PMID 20805101

Buxbaum, LJ, Kalénine, S. Action knowledge, visuomotor activation, and embodiment in the two action systems. Annals of the New York Academy of Sciences, Annals of the New York Academy of Sciences, 1191: 201-218, 2010. PMID 20392282

Jax, S., and Buxbaum, LJ. Response interference between functional and structural actions linked to the same familiar object. Cognition, 115(2): 350-355, 2010. PMID 20156619

Myung, J-Y, Blumstein, SE, Yee, E, Sedivy, JC, Thompson-Schill, S, Buxbaum, LJ. Impaired access to manipulation features in apraxia: Evidence from eyetracking and semantic judgment tasks. Brain and Language, 112(2):101-12, 2010. PMID 20064657

Dawson, AM, Buxbaum, LJ, Duff, S. The impact of left hemisphere stroke on force control with familiar and novel objects: Neuroanatomic substrates and relationship to apraxia. Brain Research, 1317: 124-36, 2010. PMID 19945445

Botvinick, MM, Buxbaum, LJ, Bylsma LM, Jax, SA. Toward an integrated account of object and action selection: A computational analysis and empirical findings from reaching-to-grasp and tool use. Neuropsychologia, 47, 671-683, 2009. PMID 19100758

Jax, S, Buxbaum, LJ., Lie, E., Coslett, HB. More than (where the target) meets the eyes: Disrupted visuomotor transformations in optic ataxia. Neuropsychologia, 47 (1), 230-238, 2009. PMID 18725238

Coslett, HB., Schwoebel, J, Buxbaum, LJ, Accurate reaching after active but not passive movements of the hand: evidence for forward modeling. Behavioral Neurology, 19(3), 117-125, 2008.

Dawson, AM., Buxbaum, LJ, Rizzo, AA. The Virtual Reality Lateralized Attention Test: Sensitivity and validity of a new clinical tool for assessing hemispatial neglect. IEEE XPlore, Virtual Rehabilitation, Issue 25-27, 77-82, 2008.

Buxbaum, LJ, Palermo, M, Mastrogiovanni, D, Schmidt, M, Rosenberg-Pitonyak, E, Jax, SA, Coslett, HB. Assessment of spatial attention and neglect with a virtual wheelchair navigation task. Journal of Clinical and Experimental Neuropsychology, 30(6), 650-660, 2008. PMID 18608643

Buxbaum, LJ, Haaland, KY, Hallett, M, Wheaton, L, Heilman, KM, Rodriguez, A, Gonzalez-Rothi, L. Treatment of limb apraxia: Moving forward to improved action. American Journal of Physical Medicine and Rehabilitation, 87(2), 149-161, 2008. PMID 18209511

Barde, LHF, Buxbaum, LJ, Moll, A. Abnormal reliance on object structure in apraxics' learning of novel object-related actions. Journal of the International Neuropsychological Society, 13(6), 997-1008, 2007. PMID 17942018

Giovannetti, T., Schwartz, MF, Buxbaum, LJ. The Coffee Challenge: A new method for the study of everyday action errors. Journal of Clinical and Experimental Neuropsychology, 29(7), 690-705, 2007. PMID 17891679

Buxbaum, LJ, Ferraro, M, Whyte, J, Coslett, HB, Gershkoff, A. Amantadine treatment of hemispatial neglect: a double-blind, placebo-controlled study. American Journal of Physical Medicine and Rehabilitation, 86(7), 527-537, 2007. PMID 17581287

Buxbaum, LJ, Kyle, KM, Grossman, M, Coslett, HB. Left inferior parietal representations for skilled hand-object interactions: Evidence from stroke and corticobasal degeneration. Cortex, 43(3), 411-23, 2007. PMID 17533764

Jax, S., Buxbaum, LJ, Moll, A. Deficits in movement planning and intrinsic coordinate control in ideomotor apraxia. Journal of Cognitive Neuroscience, 18(12), 2063-2076, 2006. PMID 17129191

Buxbaum LJ, Kyle KM, Tang K, Detre JA. Neural substrates of knowledge of hand postures for object grasping and functional object use: Evidence from fMRI. Brain Res. 2006 Sep 6; PMID 16962075

McCrae, SM, Buxbaum, LJ, Coslett, HB. Illusory conjunctions in simultanagnosia: Course coding of visual feature location? Neuropsychologia, 44(10), 1724-36, 2006. PMID 16643968

Barrett, AM, Buxbaum, LJ, Coslett, HB, Heilman, KM, Hillis, AG, , Millberg, W. Cognitive rehabilitation interventions for neglect and related disorders: moving from bench to bedside in stroke patients. Journal of Cognitive Neuroscience, 18(7), 1223-1236, 2006. PMID 16839294

Buxbaum, LJ, Kyle, KM, Tang, K, Detre, JM. Neural substrates of knowledge of hand postures for object grasping and functional object use: Evidence from fMRI. Brain Research, 1117( 1) 175-185, 2006. PMID 16962075

Biran, I., Giovannetti, T, Buxbaum LJ, Chatterjee A. The alien hand syndrome: what makes the alien hand alien? Cognitive Neuropsychology, 23(4), 563-582, 2006. PMID 21049344

Buxbaum, LJ. On the right (and left) track: Twenty years of progress in studying hemispatial neglect. Cognitive Neuropsychology, 23(1), 184-201, 2006. PMID 21049327

Buxbaum, LJ, Kyle, K, Menon R. On beyond mirror neurons: Internal representations subserving imitation and recognition of skilled object-related actions in humans. Cognitive Brain Research, 25(1), 226-239, 2005. PMID 15996857

Boronat, C., Buxbaum, LJ, Coslett, HB, Tang, K, Saffran, EM, Kimberg, DY, Detre, JA. Distinctions between function and manipulation knowledge of objects: Evidence from functional magnetic resonance imaging. Cognitive Brain Research, 23(2-3), 361-373, 2005. PMID 15820643

Buxbaum, LJ, Johnson, SH, Bartlett-Williams, M. Deficient internal models for planning hand-object interactions in ideomotor apraxia. Neuropsychologia, 43(6), 917-929, 2005. PMID 15716162

Giovannetti, T, Buxbaum, LJ, Chatterjee, A., Biran, I. Reduced endogenous control in anarchic hand syndrome: Evidence from naturalistic action. Neuropsychologia, 43, 75-88, 2005. PMID 15488908